Viral myocarditis and dilated cardiomyopathy — an experimental study with special reference to immunological behaviour of T- and B-lymphocytes

摘要

The direct transition from acute myocarditis to dilated cardiomyopathy has been demonstrated in an inbred strain of DBA/2 mice inoculated with the M-variant of EMC virus. The severity of myocarditis, which determines the development of congestive heart failure and, later, the diseased state resembling dilated cardiomyopathy, seems to be mediated by T-lymphocytes.